Richard Anderson Lab
  • Agonist-stimulated PI 3-kinase and Erk kinase pathways are controlled by IQGAP1
  • Cell Migration, Invasion and Metastasis
  • Phosphoinositide Signaling in the Nucleus
  • Receptor Control of Autophagy
  • Spatial and Receptor Signaling at the Endosome
  • Structure and Function of Signaling Molecules
  • Translational Applications to Human Diseases
Research: Agonist stimulated signaling pathways are assembled by IQGAP scaffolds1 Research: Cell Migration, Invasion and Metastasis2 Research: Phosphoinositide Signaling in the Nucleus3 Research: Receptor Control of Autophagy4 Research: Spatial and Receptor Signaling in the Endosome5 Research: Structure and Function of Signaling Molecules6 Research: Translational Applications to Human Diseases7

Phosphoinositide Spatial and Regulatory Mechanisms that Control Cellular Functions

Our laboratory is focused on understanding the signaling transduction and regulatory pathways that impact cancer progression and metastasis, neurodegenerative diseases, diabetes and cardiovascular diseases.

 

A focus is on spatial organization of cellular signaling. Very recently spatial organization of cellular signals and messengers such as lipid messenger signals has been shown to be fundamental in regulating most, perhaps all, cellular events. The group currently focuses on cell polarization in control of migration and invasion in cancer cell metastasis, the role of membrane trafficking in regulation of growth receptor signaling and control of autophagy, and the control of gene expression by nuclear located lipid messengers. For these studies we use many interdisciplinary approaches, including cell biology, biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.

 

Our research foundation is basic research, yet we also seek to define how the basic signaling and regulatory pathways that we have discovered are fundamental to a wide variety of human epithelial cancers, including breast, head and neck cancers and lung cancers.

 

The work focused on cell migration and autophagy has clear implications for cardiovascular and neurodegenerative diseases. The role of nuclear lipid messengers in gene expression represents a fundamental discovery with implications to all aspects of human biology and disease.

 

An emphasis of our group is the training of young scholars in scientific research.

Anderson Lab News

April 11, 2017

There are currently four positions open in the laboratory for Postdocs, Scientists or graduate students. Please send CV and letter of interest to: Richard A. Anderson, E-mail: raanders@wisc.edu

November 23, 2016

Nine news articles that cited Suyong’s paper that is published in Nature Cell Biology. These include a news release from the University of Wisconsin, Cancer signaling pathway could illuminate new avenue to therapy and eight others that where noted by the Nature Website.

In addition, there was a News and Views that was written about this paper.

July 2, 2015

Rakesh’s paper is now accepted at NAR. Congratulations to all the authors. Mohan N, Sudheesh AP, Francis N, Anderson. R.A. and Laishram, R.S., (2015) Mohan N, Sudheesh AP, Francis N, Anderson. R.A. and Laishram, R.S., (2015) Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets. Nucleic Acids Res. 43, 7005-20. PMID: 26138484, PMCID: PMC4538844

January 16, 2015

Suyong’s paper is now accepted at BBA. Congratulations to all the authors. Choi, S., Thapa, N., Tan, X., Hedman, A.C. & Anderson, R.A. (2015) PIP kinases define PI4,5P₂signaling specificity by association with effectors. Biochimica et biophysica acta 1851, 711-723. PMID: 25617736, PMCID: PMC4380618

January 15, 2015

Xiaojun’s paper is now accepted at Cell. Congratulations to all the authors. Tan, X., Thapa, N., Sun, Y. & Anderson, R.A. (2015) A kinase-independent role for EGF receptor in autophagy initiation. Cell 160, 145-160. PMID: 25594178, PMCID: PMC4297316.

December 12, 2014

Xiaojun’s paper is now accepted at EMBO. Congratulations to all the authors. Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. (2015) LAPTM4B is a PtdIns(4,5)P₂effector that regulates EGFR signaling, lysosomal sorting, and degradation. The EMBO Journal. 34, 475-90. PMID: 25588945, "PMCID: PMC4331002

November 19, 2014

Xiaojun’s paper is now accepted at Cell. Congratulations to all the authors.

Xiaojun Tan, Narendra Thapa, Yue Sun and Richard A Anderson (2014) A Kinase Independent Role for the EGF Receptor in Autophagy Initiation. In press, Cell.

July 27, 2014

Group attended the FASEB meeting on, “FASEB 2014- Lipids and Lipid Regulated Kinases in Cancer, July 27-August 1, 2014 in Steamboat Springs, Colorado. Richard is speaking, “Lipid messengers in the nucleus control PTEN expression.”

Narendra Thapa is a speaker also “Phosphatidylinositol Phosphate 5-Kinase gamma (PIPKIγ) Regulates Migration and Anchorage-independent Growth of Tumor Cells.

May 25, 2014

Nick Schills paper is in press at J. Cell Science and Emphasized in the JCS Snapshot. Congratulations to all the authors.

Schill, N.J., Hedman, A.C., Choi, S. and Anderson, R.A. (2014) Isoform 5 of PIPKIγ Regulates the Endosomal Trafficking and Degradation of E-cadherin. J. Cell Science. 127, 2189–2203 PMID: 24610942 PMCID: PMC4021470 Emphasized in the JCS Snapshot.

May 5, 2013

Suyong Choi paper is accepted at The EMBO Journal. Have a good read.

Choi, S., Thapa, N., Sacks, D., and Anderson, R.A. (2013) Directional Cell Migration is Regulated by an IQGAP1 and Type Iγ Phosphatidylinositol Phosphate Kinase Signaling Nexus. The EMBO Journal 32, 2617-30, PMID: 23982733, PMCID: PMC3791370