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7Phosphoinositide Spatial and Regulatory Mechanisms that Control Cellular Functions
Our laboratory is focused on understanding the signaling transduction and regulatory pathways that impact cancer progression and metastasis, neurodegenerative diseases, diabetes and cardiovascular diseases.
A focus is on spatial organization of cellular signaling. Very recently spatial organization of cellular signals and messengers such as lipid messenger signals has been shown to be fundamental in regulating most, perhaps all, cellular events. The group currently focuses on cell polarization in control of migration and invasion in cancer cell metastasis, the role of membrane trafficking in regulation of growth receptor signaling and control of autophagy, and the control of gene expression by nuclear located lipid messengers. For these studies we use many interdisciplinary approaches, including cell biology, biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.
Our research foundation is basic research, yet we also seek to define how the basic signaling and regulatory pathways that we have discovered are fundamental to a wide variety of human epithelial cancers, including breast, head and neck cancers and lung cancers.
The work focused on cell migration and autophagy has clear implications for cardiovascular and neurodegenerative diseases. The role of nuclear lipid messengers in gene expression represents a fundamental discovery with implications to all aspects of human biology and disease.
An emphasis of our group is the training of young scholars in scientific research.
Anderson Lab News
April 11, 2017
There are currently four positions open in the laboratory for Postdocs, Scientists or graduate students. Please send CV and letter of interest to: Richard A. Anderson, E-mail: raanders@wisc.edu
March 20, 2017
Choi’s News and Views in now published. Congratulations!
February 16, 2017
Narendra’s paper is now accepted at Oncogene. Congratulations to all the authors.
November 23, 2016
Nine news articles that cited Suyong’s paper that is published in Nature Cell Biology. These include a news release from the University of Wisconsin, Cancer signaling pathway could illuminate new avenue to therapy and eight others that where noted by the Nature Website.
In addition, there was a News and Views that was written about this paper.
November 21, 2016
Suyong’s paper is now accepted at Nature. Congratulations to all the authors. Choi, S., Hedman, A.C. Sayedyahossein, S. Thapa, N. Sacks, D.B. and Anderson, R.A. (2016) Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases. Nature Cell Biology 18, 1324–1335. PMID: 27870828.
October 7, 2016
Yue’s paper is now accepted at JBC. Congratulations to all the authors. Sun, M., Cai, J., Anderson, R.A., and Sun, Y. (2016) Type I Gamma Phosphatidylinositol Phosphate 5-kinase i5 Controls the Ubiquitination and Degradation of a Tumor Suppressor Mitogen-inducible Gene 6. J. Biol. Chem. 291(41):21461-21473. PMID: 27557663, PMCID: PMC5076818
June 20, 2016
Narendra’s paper is now accepted at Trends in Cancer. Congratulations to all the authors. Thapa, N., Tan, X., Choi, S., Rapreager, A. Lambert, P. and Anderson, R. A. (2016) The Hidden Conundrum of Phosphoinositide Signaling in Cancer. Trends in Cancer, 2, 378–390. PMID: 27819060, PMCID: PMC5094282
January 27, 2016
Xiaojun’s paper is now accepted at Trends in Cell Biology. Congratulations to all the authors. Tan, X., Lambert, P.F., Rapraeger, A.C. & Anderson, R.A. (2106) Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications. Trends in Cell Biology, 26, 352-66. PMID: 26827089, doi:10.1016/j.tcb.2015.12.006. PMC Journal.
November 23, 2015
Xiaojun’s paper is now accepted at PNAS. Congratulations to all the authors. Tan X, Thapa, N., Liao, Y. and Anderson R.A. (2016) PtdIns(4,5)P₂ Signaling Regulates ATG14 and Autophagy. Proc. Natl. Acad. Sci. U.S.A. 113, 10896-901. PMID: 27621469, PMCID: PMC5047215
November 15, 2015
Xiaojun’s paper is now accepted at J. Cell Science. Congratulations to all the authors. Tan, X., Thapa, N., Choi, S., and Anderson, R.A. (2015) Emerging roles of PtdIns(4,5)P₂ - beyond the plasma membrane. J. Cell Science, 128(22), 4047-56. PMID: 26574506, PMCID: PMC4712784
October 28, 2015
Suyong’s paper is now accepted at Adv Enzyme Regul. Congratulations to all the authors. Choi, S. and Anderson, R.A. (2015) IQGAP1 is a Phosphoinositide Effector and Kinase Scaffold. Adv Enzyme Regul: S2212-4926(15)30027-0. PMID: 26554303, PMCID: PMC4729663
July 2, 2015
Rakesh’s paper is now accepted at NAR. Congratulations to all the authors. Mohan N, Sudheesh AP, Francis N, Anderson. R.A. and Laishram, R.S., (2015) Mohan N, Sudheesh AP, Francis N, Anderson. R.A. and Laishram, R.S., (2015) Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets. Nucleic Acids Res. 43, 7005-20. PMID: 26138484, PMCID: PMC4538844
June 12, 2015
Narendra’s paper is now accepted at JBC. Congratulations to all the authors. Thapa, N., Choi, S., Tan, X., and Anderson, R. A. (2014) Phosphatidylinositol Phosphate 5-Kinase Igamma and PI3K/Akt Signaling Couple to Promote Oncogenic Growth. J. Biol. Chem.
January 16, 2015
Suyong’s paper is now accepted at BBA. Congratulations to all the authors. Choi, S., Thapa, N., Tan, X., Hedman, A.C. & Anderson, R.A. (2015) PIP kinases define PI4,5P₂signaling specificity by association with effectors. Biochimica et biophysica acta 1851, 711-723. PMID: 25617736, PMCID: PMC4380618
January 15, 2015
Xiaojun’s paper is now accepted at Cell. Congratulations to all the authors. Tan, X., Thapa, N., Sun, Y. & Anderson, R.A. (2015) A kinase-independent role for EGF receptor in autophagy initiation. Cell 160, 145-160. PMID: 25594178, PMCID: PMC4297316.
January 15, 2015
UW-Madison scientists find how many cancers may evade treatment.
December 12, 2014
Xiaojun’s paper is now accepted at EMBO. Congratulations to all the authors. Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. (2015) LAPTM4B is a PtdIns(4,5)P₂effector that regulates EGFR signaling, lysosomal sorting, and degradation. The EMBO Journal. 34, 475-90. PMID: 25588945, "PMCID: PMC4331002
November 19, 2014
Xiaojun’s paper is now accepted at Cell. Congratulations to all the authors.
Xiaojun Tan, Narendra Thapa, Yue Sun and Richard A Anderson (2014) A Kinase Independent Role for the EGF Receptor in Autophagy Initiation. In press, Cell.
July 27, 2014
Group attended the FASEB meeting on, “FASEB 2014- Lipids and Lipid Regulated Kinases in Cancer, July 27-August 1, 2014 in Steamboat Springs, Colorado. Richard is speaking, “Lipid messengers in the nucleus control PTEN expression.”
Narendra Thapa is a speaker also “Phosphatidylinositol Phosphate 5-Kinase gamma (PIPKIγ) Regulates Migration and Anchorage-independent Growth of Tumor Cells.
May 25, 2014
Nick Schills paper is in press at J. Cell Science and Emphasized in the JCS Snapshot. Congratulations to all the authors.
Schill, N.J., Hedman, A.C., Choi, S. and Anderson, R.A. (2014) Isoform 5 of PIPKIγ Regulates the Endosomal Trafficking and Degradation of E-cadherin. J. Cell Science. 127, 2189–2203 PMID: 24610942 PMCID: PMC4021470 Emphasized in the JCS Snapshot.
May 5, 2013
Suyong Choi paper is accepted at The EMBO Journal. Have a good read.
Choi, S., Thapa, N., Sacks, D., and Anderson, R.A. (2013) Directional Cell Migration is Regulated by an IQGAP1 and Type Iγ Phosphatidylinositol Phosphate Kinase Signaling Nexus. The EMBO Journal 32, 2617-30, PMID: 23982733, PMCID: PMC3791370